ASK YOUR HEMODIALYSIS PATIENTS ABOUT
THEIR REPORTED CKD-aP SYMPTOMS

On the surface, CKD-aP may be just an itch. But for hemodialysis patients living with CKD-aP, the consequences are much more.

Discover how CKD-aP may impact many aspects of your patients’ lives.1,2

Are your patients suffering from CKD-aP?
Most CKD patients on hemodialysis reported suffering from CKD-aP1

65% of HD patients in the U.S. in the Dialysis Outcomes and Practice Patterns Study (DOPPS)* reported that they suffered from CKD-aP.†

HD=hemodialysis.
*Phases 4–6 of DOPPS (a prospective cohort study) included 34,694 HD patients in 21 countries from 2009–2018; 23,264 patients were eligible for analysis of the primary outcome. The primary clinical outcome was time to all-cause mortality; dialysis-related outcomes included withdrawal from dialysis and missed hemodialysis sessions; patient-reported outcomes included measure of health-related quality of life, depression, and sleep quality.
†Figure calculated based on total patients reporting being somewhat to extremely bothered by itching.
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When CKD-aP may be more than just an itch
CKD-aP may impact many aspects of patients’ lives1,2

CKD patients undergoing hemodialysis have many challenges going on in their lives. These can be exacerbated by CKD-aP.3

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A multifactorial pathophysiology
A multifactorial pathophysiology

Research suggests that the pathophysiology of CKD-aP is multifactorial and may be caused by opioid dysregulation, immune system dysfunction, toxin deposition, and/or peripheral neuropathy.4

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Management of CKD-aP
Consider the management of CKD-aP in HD patients

CKD-aP management should be multifaceted and tailored to each patient’s dialysis goals, as no single approach has been shown to be effective.4,5

HD=hemodialysis.
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CKD=chronic kidney disease.

References
References
  1. Sukul N, Karaboyas A, Csomor PA, et al. Self-reported pruritus and clinical, dialysis-related, and patient-reported outcomes in hemodialysis patients. Kidney Med. 2020;3(1):42–53. doi:10.1016/j.xkme.2020.08.011
  2. Rayner HC, Larkina M, Wang M, et al. International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis. Clin J Am Soc Nephrol. 2017;12(12):2000–2007. doi:10.2215/CJN.03280317
  3. Ramakrishnan K, Bond CT, Claxton A, et al. Clinical characteristics and outcomes of end-stage renal disease patients with self-reported pruritus symptoms. Int J Nephrol Renovasc Dis. 2014;7:1–12. doi:10.2147/IJNRD.S52985
  4. Verduzco HA, Shirazian S. CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management. Kidney Int Rep. 2020;5(9):1387–1402. doi:10.1016/j.ekir.2020.04.027
  5. Millington GWM, Collins A, Lovell CR, et al. British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018. Br J Dermatol. 2018;178(1):34–60. doi:10.1111/bjd.16117