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Management

This section is for general information about CKD-aP only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

CKD-aP management should be multifaceted and tailored to each patient’s dialysis goals, as no single approach has been shown overwhelmingly to be effective1,2
Options to manage CKD-aP are limited2
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The first step in CKD-aP management is to optimize dialysis; however, this may not be sufficient, given the multifactorial pathogenesis1,3

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Some therapeutic interventions may reduce severity of itch, but these are limited in their long-term use and are therefore often discontinued4–6

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Some therapeutic interventions may reduce severity of itch, but these are limited in their long-term use and are therefore often discontinued4–6

CKD-aP=chronic kidney disease–associated pruritus.

It’s time to change the outlook in CKD-aP

Changing the outlook of CKD-aP starts by talking about it—
let your patients be heard.

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References
References
  1. Millington GWM, Collins A, Lovell CR, et al. British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018. Br J Dermatol. 2018;178(1):34–60. doi:10.1111/bjd.16117
  2. Verduzco HA, Shirazian S. CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management. Kidney Int Rep. 2020;5(9):1387–1402. doi:10.1016/j.ekir.2020.04.027
  3. Rayner HC, Larkina M, Wang M, et al. International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis. Clin J Am Soc Nephrol. 2017;12(12):2000–2007. doi:10.2215/CJN.03280317
  4. Mathur VS, Lindberg J, Germain M, et al. A longitudinal study of uremic pruritus in hemodialysis patients. Clin J Am Soc Nephrol. 2010;5(8):1410–1419. doi:10.2215/CJN.00100110
  5. Simonsen E, Komenda P, Lerner B, et al. Treatment of uremic pruritus: a systematic review. Am J Kidney Dis. 2017;70(5):638–655. doi:10.1053/j.ajkd.2017.05.018
  6. Combs SA, Teixeira JP, Germain MJ. Pruritus in kidney disease. Semin Nephrol. 2015;35(4):383–391. doi:10.1016/j.semnephrol.2015.06.009